Human monocytes downregulate innate response receptors following exposure to the microbial metabolite n-butyrate.

ABSTRACT:

Introduction

Hyporesponsiveness of human lamina propria immune cells to microbial and nutritional antigens represents one important feature of intestinal homeostasis. It is at least partially mediated by low expression of the innate response receptors CD11b, CD14, CD16 as well as the cystine-glutamate transporter xCT on these cells. Milieu-specific mechanisms leading to the down-regulation of these receptors on circulating monocytes, the precursor cells of resident macrophages, are mostly unknown.

Methods

Here, we addressed the question whether the short chain fatty acid n-butyrate, a fermentation product of the mammalian gut microbiota exhibiting histone deacetylase inhibitory activity, is able to modulate expression of these receptors in human circulating monocytes.

Res

SUBMITTER: Lasitschka F 

PROVIDER: S-EPMC5691313 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature