MicroRNA and mRNA Dysregulation in Astrocytes Infected with Zika Virus.

ABSTRACT: The Zika virus (ZIKV) epidemic is an ongoing public health concern. ZIKV is a flavivirus reported to be associated with microcephaly, and recent work in animal models demonstrates the ability of the virus to cross the placenta and affect fetal brain development. Recent findings suggest that the virus preferentially infects neural stem cells and thereby deregulates gene expression, cell cycle progression, and increases cell death. However, neuronal stem cells are not the only brain cells that are susceptible to ZIKV and infection of other brain cells may contribute to disease progression. Herein, we characterized ZIKV replication in astrocytes, and profiled temporal changes in host microRNAs (miRNAs) and transcriptomes during infection. We observed the deregulation of numerous processes kno

SUBMITTER: Kozak RA 

PROVIDER: S-EPMC5691648 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature