Choline and Working Memory Training Improve Cognitive Deficits Caused by Prenatal Exposure to Ethanol.

ABSTRACT: Prenatal ethanol exposure is associated with deficits in executive function such as working memory, reversal learning and attentional set shifting in humans and animals. These behaviors are dependent on normal structure and function in cholinergic brain regions. Supplementation with choline can improve many behaviors in rodent models of fetal alcohol spectrum disorders and also improves working memory function in normal rats. We tested the hypothesis that supplementation with choline in the postnatal period will improve working memory during adolescence in normal and ethanol-exposed animals, and that working memory engagement during adolescence will transfer to other cognitive domains and have lasting effects on executive function in adulthood. Male and female offspring of rats fed an etha

SUBMITTER: Waddell J 

PROVIDER: S-EPMC5691697 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature