Synergistic malaria vaccine combinations identified by systematic antigen screening.

ABSTRACT: A highly effective vaccine would be a valuable weapon in the drive toward malaria elimination. No such vaccine currently exists, and only a handful of the hundreds of potential candidates in the parasite genome have been evaluated. In this study, we systematically evaluated 29 antigens likely to be involved in erythrocyte invasion, an essential developmental stage during which the malaria parasite is vulnerable to antibody-mediated inhibition. Testing antigens alone and in combination identified several strain-transcending targets that had synergistic combinatorial effects in vitro, while studies in an endemic population revealed that combinations of the same antigens were associated with protection from febrile malaria. Video microscopy established that the most effective combinations tar

SUBMITTER: Bustamante LY 

PROVIDER: S-EPMC5692528 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature