Thin myelin sheaths as the hallmark of remyelination persist over time and preserve axon function.

ABSTRACT: The presence of thin myelin sheaths in the adult CNS is recognized as a marker of remyelination, although the reason there is not a recovery from demyelination to normal myelin sheath thickness remains unknown. Remyelination is the default pathway after myelin loss in all mammalian species, in both naturally occurring and experimental disease. However, there remains uncertainty about whether these thin sheaths thicken with time and whether they remain viable for extended periods. We provide two lines of evidence here that thin myelin sheaths may persist indefinitely in long-lived animal models. In the first, we have followed thin myelin sheaths in a model of delayed myelination during a period of 13 years that we propose results in the same myelin sheath deficiencies as seen in remyelinati

SUBMITTER: Duncan ID 

PROVIDER: S-EPMC5692595 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature