Using multi-level Bayesian lesion-symptom mapping to probe the body-part-specificity of gesture imitation skills.

ABSTRACT: Past attempts to identify the neural substrates of hand and finger imitation skills in the left hemisphere of the brain have yielded inconsistent results. Here, we analyse those associations in a large sample of 257 left hemisphere stroke patients. By introducing novel Bayesian methods, we characterise lesion symptom associations at three levels: the voxel-level, the single-region level (using anatomically defined regions), and the region-pair level. The results are inconsistent across those three levels and we argue that each level of analysis makes assumptions which constrain the results it can produce. Regardless of the inconsistencies across levels, and contrary to past studies which implicated differential neural substrates for hand and finger imitation, we find no consistent voxels o

SUBMITTER: Achilles EIS 

PROVIDER: S-EPMC5692920 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature