ProSAAS-derived peptides are regulated by cocaine and are required for sensitization to the locomotor effects of cocaine.

ABSTRACT: To identify neuropeptides that are regulated by cocaine, we used a quantitative peptidomic technique to examine the relative levels of neuropeptides in several regions of mouse brain following daily intraperitoneal administration of 10 mg/kg cocaine or saline for 7 days. A total of 102 distinct peptides were identified in one or more of the following brain regions: nucleus accumbens, caudate putamen, frontal cortex, and ventral tegmental area. None of the peptides detected in the caudate putamen or frontal cortex were altered by cocaine administration. Three peptides in the nucleus accumbens and seven peptides in the ventral tegmental area were significantly decreased in cocaine-treated mice. Five of these ten peptides are derived from proSAAS, a secretory pathway protein and neuropeptide

SUBMITTER: Berezniuk I 

PROVIDER: S-EPMC5693316 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature