Vitamin D supplementation to prevent asthma exacerbations: a systematic review and meta-analysis of individual participant data.

ABSTRACT:

Background

A previous aggregate data meta-analysis of randomised controlled trials showed that vitamin D supplementation reduces the rate of asthma exacerbations requiring treatment with systemic corticosteroids. Whether this effect is restricted to patients with low baseline vitamin D status is unknown.

Methods

For this systematic review and one-step and two-step meta-analysis of individual participant data, we searched MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, and Web of Science for double-blind, placebo-controlled, randomised controlled trials of vitamin D₃ or vitamin D₂ supplementation in people with asthma that reported incidence of asthma exacerbation, published between database inception and Oct 26, 2016. We analysed in

SUBMITTER: Jolliffe DA 

PROVIDER: S-EPMC5693329 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature