Octopamine Drives Endurance Exercise Adaptations in Drosophila.

ABSTRACT: Endurance exercise is an effective therapeutic intervention with substantial pro-healthspan effects. Male Drosophila respond to a ramped daily program of exercise by inducing conserved physiological responses similar to those seen in mice and humans. Female flies respond to an exercise stimulus but do not experience the adaptive training response seen in males. Here, we use female flies as a model to demonstrate that differences in exercise response are mediated by differences in neuronal activity. The activity of octopaminergic neurons is specifically required to induce the conserved cellular and physiological changes seen following endurance training. Furthermore, either intermittent, scheduled activation of octopaminergic neurons or octopamine feeding is able to fully substitute for exe

SUBMITTER: Sujkowski A 

PROVIDER: S-EPMC5693351 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature