A Tug-of-War Mechanism for Pattern Formation in a Genetic Network.

ABSTRACT: Synthesizing spatial patterns with genetic networks is an ongoing challenge in synthetic biology. A successful demonstration of pattern formation would imply a better understanding of systems in the natural world and advance applications in synthetic biology. In developmental systems, transient patterning may suffice in order to imprint instructions for long-term development. In this paper we show that transient but persistent patterns can emerge from a realizable synthetic gene network based on a toggle switch. We show that a bistable system incorporating diffusible molecules can generate patterns that resemble Turing patterns but are distinctly different in the underlying mechanism: diffusion of mutually inhibiting molecules creates a prolonged "tug-of-war" between patches of cells at op

SUBMITTER: Gomez MM 

PROVIDER: S-EPMC5693606 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature