Interferon-γ Treatment of Human Laryngotracheal Stenosis-Derived Fibroblasts.

ABSTRACT:

Importance

Laryngotracheal stenosis (LTS) is a fibroproliferative disorder of the glottis, subglottis, and trachea. In models of fibrosis from other organ systems, the CD4+ T-cell response has been shown to regulate extracellular matrix deposition. Specifically, helper T cell 2 (TH2) promotes fibrosis, whereas TH1 and associated cytokines have been shown to be antifibrotic. However, this antifibrotic effect of the TH1 response has not been demonstrated in LTS.

Objective

To determine whether the TH1 cytokine interferon-γ inhibits the function of LTS-derived fibroblasts in vitro.

Design, setting, and participants

This in vitro controlled study included 6 patients with iatrogenic LTS undergoing routine surgical subglottic and tracheal dilation at a single institution. Fi

SUBMITTER: Motz K 

PROVIDER: S-EPMC5693677 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature