Pediatric Sepsis Endotypes Among Adults With Sepsis.

ABSTRACT:

Objectives

Recent transcriptomic studies describe two subgroups of adults with sepsis differentiated by a sepsis response signature. The implied biology and related clinical associations are comparable with recently reported pediatric sepsis endotypes, labeled "A" and "B." We classified adults with sepsis using the pediatric endotyping strategy and the sepsis response signature and determined how endotype assignment, sepsis response signature membership, and age interact with respect to mortality.

Design

Retrospective analysis of publically available transcriptomic data representing critically ill adults with sepsis from which the sepsis response signature groups were derived and validated.

Setting

Multiple ICUs.

Patients

Adults with sepsis.

Interventions

SUBMITTER: Wong HR 

PROVIDER: S-EPMC5693699 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature