Whole exome sequencing of wild-derived inbred strains of mice improves power to link phenotype and genotype.

ABSTRACT: The house mouse is a powerful model to dissect the genetic basis of phenotypic variation, and serves as a model to study human diseases. Despite a wealth of discoveries, most classical laboratory strains have captured only a small fraction of genetic variation known to segregate in their wild progenitors, and existing strains are often related to each other in complex ways. Inbred strains of mice independently derived from natural populations have the potential to increase power in genetic studies with the addition of novel genetic variation. Here, we perform exome-enrichment and high-throughput sequencing (~8× coverage) of 26 wild-derived strains known in the mouse research community as the "Montpellier strains." We identified 1.46 million SNPs in our dataset, approximately 19% of which h

SUBMITTER: Chang PL 

PROVIDER: S-EPMC5693759 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature