TSPO imaging using the novel PET ligand [¹⁸F]GE-180: quantification approaches in patients with multiple sclerosis.

ABSTRACT:

Background

PET ligands targeting the translocator protein (TSPO) represent promising tools to visualise neuroinflammation. Here, we analysed parameters obtained in dynamic and static PET images using the novel TSPO ligand [¹⁸F]GE-180 in patients with relapsing remitting multiple sclerosis (RRMS) and an approach for semi-quantitative assessment of this disease in clinical routine. Seventeen dynamic [¹⁸F]GE-180 PET scans of RRMS patients were evaluated (90 min). A pseudo-reference region (PRR) was defined after identification of the least disease-affected brain area by voxel-based comparison with six healthy controls (HC) and upon exclusion of voxels suspected of being affected in static 60-90 min p.i. images. Standardised uptake value ratios (SUVR) obtained fro

SUBMITTER: Vomacka L 

PROVIDER: S-EPMC5693838 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature