Transcriptional signature of human pro-inflammatory T_H17 cells identifies reduced IL10 gene expression in multiple sclerosis.

ABSTRACT: We have previously reported the molecular signature of murine pathogenic T_H17 cells that induce experimental autoimmune encephalomyelitis (EAE) in animals. Here we show that human peripheral blood IFN-γ⁺IL-17⁺ (T_H1/17) and IFN-γ^-IL-17⁺ (T_H17) CD4⁺ T cells display distinct transcriptional profiles in high-throughput transcription analyses. Compared to T_H17 cells, T_H1/17 cells have gene signatures with marked similarity to mouse pathogenic T_H17 cells. Assessing 15 representative signature genes in patients with multiple sclerosis, we find that T_H1/17 cells have elevated expression of CXCR3 and reduced expression of IFNG, CCL3, CLL4, GZMB, and IL10 compared to he

SUBMITTER: Hu D 

PROVIDER: S-EPMC5693957 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature