Deletion of the activating NK cell receptor NKG2D accelerates rejection of cardiac allografts.

ABSTRACT: It has already been shown that neutralization of the activating NK cell receptor NKG2D in combination with co-stimulation blockade prolongs graft survival of vascularized transplants. In order to clarify the underlying cellular mechanisms, we transplanted complete MHC-disparate BALB/c-derived cardiac grafts into C57BL/6 wildtypes or mice deficient for NKG2D (Klrk1^-/- ). Although median survival was 8 days for both recipient groups, we detected already at day 5 posttransplantation significantly greater intragraft frequencies of NKp46⁺ NK cells in Klrk1^-/- recipients than in wildtypes. This was followed by a significantly greater infiltration of CD4⁺ , but a lesser infiltration of CD8⁺ T cell frequencies. Contrary to published observatio

SUBMITTER: Fabritius C 

PROVIDER: S-EPMC5694344 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature