Active Surveillance Versus Watchful Waiting for Localized Prostate Cancer: A Model to Inform Decisions.

ABSTRACT:

Background

An increasing proportion of prostate cancer is being managed conservatively. However, there are no randomized trials or consensus regarding the optimal follow-up strategy.

Objective

To compare life expectancy and quality of life between watchful waiting (WW) versus different strategies of active surveillance (AS).

Design, setting, and participants

A Markov model was created for US men starting at age 50, diagnosed with localized prostate cancer who chose conservative management by WW or AS using different testing protocols (prostate-specific antigen every 3-6 mo, biopsy every 1-5 yr, or magnetic resonance imaging based). Transition probabilities and utilities were obtained from the literature.

Outcome measurements and statistical analysis

Primary out

SUBMITTER: Loeb S 

PROVIDER: S-EPMC5694372 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature