5-Fluorouracil and irinotecan (SN-38) have limited impact on colon microbial functionality and composition in vitro.

ABSTRACT: Gastrointestinal mucositis is a debilitating side effect of chemotherapy treatment, with currently no treatment available. As changes in microbial composition have been reported upon chemotherapy treatment in vivo, it is thought that gut microbiota dysbiosis contribute to the mucositis etiology. Yet it is not known whether chemotherapeutics directly cause microbial dysbiosis, thereby increasing mucositis risk, or whether the chemotherapeutic subjected host environment disturbs the microbiome thereby aggravating the disease. To address this question, we used the M-SHIME^®, an in vitro mucosal simulator of the human intestinal microbial ecosystem, as an experimental setup that excludes the host factor. The direct impact of two chemotherapeutics, 5-fluorouracil (5-FU)

SUBMITTER: Vanlancker E 

PROVIDER: S-EPMC5694655 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature