Identification of Optimal Mouse Models of Systemic Sclerosis by Interspecies Comparative Genomics.

ABSTRACT:

Objective

Understanding the pathogenesis of systemic sclerosis (SSc) is confounded by considerable disease heterogeneity. Animal models of SSc that recapitulate distinct subsets of disease at the molecular level have not been delineated. We applied interspecies comparative analysis of genomic data from multiple mouse models of SSc and patients with SSc to determine which animal models best reflect the SSc intrinsic molecular subsets.

Methods

Gene expression measured in skin from mice with sclerodermatous graft-versus-host disease (GVHD), bleomycin-induced fibrosis, Tsk1/+ or Tsk2/+ mice was mapped to human orthologs and compared to SSc skin biopsy-derived gene expression. Transforming growth factor β (TGFβ) activation was assessed using a responsive signature in mice, and tu

SUBMITTER: Sargent JL 

PROVIDER: S-EPMC5695038 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature