Common Polymorphisms in IFI16 and AIM2 Genes Are Associated With Periodontal Disease.

ABSTRACT:

Background

The single nucleotide polymorphism (SNP) context of a previously identified periodontitis-associated locus is investigated, and its association with microbial, biologic, and periodontal disease clinical parameters is examined.

Methods

A 200-kb spanning region of 1q12 previously highlighted in a genome-wide association scan among 4,766 European American individuals (SNP rs1633266) was annotated. Two haplotype blocks were selected. Association of these polymorphisms with data on microbial plaque composition, gingival crevicular fluid (GCF)-interleukin (IL)-1β levels, and clinical parameters of periodontal disease were examined. Descriptive analysis of IFI16 and AIM2 protein expression in gingival tissues from healthy individuals (n = 2) and individuals with chronic

SUBMITTER: Marchesan JT 

PROVIDER: S-EPMC5695043 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature