Identification and Validation of a Salivary Protein Panel to Detect Heart Failure Early.

ABSTRACT:

Background

Over 26 million people suffer from heart failure (HF) globally. Current diagnosis of HF relies on clinical evaluation, blood assays and imaging techniques. Our aim is to develop a diagnostic assay to detect HF in at risk individuals within the community using human saliva as a medium, potentially leading to a simple, safe early warning system.

Methods

Saliva samples were collected from healthy controls (n=36) and HF patients (n=75). Salivary proteome profiles were analysed by Sequential Window Acquisition of All Theoretical fragment ion spectra - Mass Spectrometry (SWATH-MS). A total of 738 proteins were quantified and 177 proteins demonstrated significant differences between HF patients and healthy controls. Candidate biomarkers were chosen based on their abundan

SUBMITTER: Zhang X 

PROVIDER: S-EPMC5695135 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature