Cardiac muscle wasting in individuals with cancer cachexia.

ABSTRACT:

Aims

Cachexia is a severe complication of cancer that adversely affects the course of the disease and is associated with high rates of mortality. Patients with cancer manifest symptoms, such as fatigue, shortness of breath, and impaired exercise tolerance, which are clinical signs of chronic heart failure. The aim of this study was to evaluate cardiac muscle wasting in cancer individuals.

Methods and results

We retrospectively analysed 177 individuals who died of cancer, including 58 lung, 60 pancreatic, and 59 gastrointestinal (GI) cancers, and 42 cancer-free controls who died of other, non-cardiovascular reasons. Cancer cachexia (CC) was defined based on clinical and/or pathological diagnosis, body mass index (BMI) <20.0 kg/m² and/or oedema-free body weight loss

SUBMITTER: Barkhudaryan A 

PROVIDER: S-EPMC5695173 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature