Genomic characterization of a local epidemic Pseudomonas aeruginosa reveals specific features of the widespread clone ST395.

ABSTRACT: Pseudomonas aeruginosa is a ubiquitous opportunistic pathogen with several clones being frequently associated with outbreaks in hospital settings. ST395 is among these so-called 'international' clones. We aimed here to define the biological features that could have helped the implantation and spread of the clone ST395 in hospital settings. The complete genome of a multidrug resistant index isolate (DHS01) of a large hospital outbreak was analysed. We identified DHS01-specific genetic elements, among which were identified those shared with a panel of six independent ST395 isolates responsible for outbreaks in other hospitals. DHS01 has the fifth largest chromosome of the species (7.1 Mbp), with most of its 1555 accessory genes borne by either genomic islands (GIs, n=48) or int

SUBMITTER: Petitjean M 

PROVIDER: S-EPMC5695207 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature