Identification of pathogen and host-response markers correlated with periodontal disease.

ABSTRACT:

Background

Periodontitis is the major cause of tooth loss in adults and is linked to systemic illnesses, such as cardiovascular disease and stroke. The development of rapid point-of-care (POC) chairside diagnostics has the potential for the early detection of periodontal infection and progression to identify incipient disease and reduce health care costs. However, validation of effective diagnostics requires the identification and verification of biomarkers correlated with disease progression. This clinical study sought to determine the ability of putative host- and microbially derived biomarkers to identify periodontal disease status from whole saliva and plaque biofilm.

Methods

One hundred human subjects were equally recruited into a healthy/gingivitis group or a periodont

SUBMITTER: Ramseier CA 

PROVIDER: S-EPMC5695217 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature