A 16-gene signature predicting prognosis of patients with oral tongue squamous cell carcinoma.

ABSTRACT:

Background

Oral tongue squamous cell carcinoma (OTSCC) is the most common subtype of oral cancer. A predictive gene signature is necessary for prognosis of OTSCC.

Methods

Five microarray data sets of OTSCC from the Gene Expression Omnibus (GEO) and one data set from The Cancer Genome Atlas (TCGA) were obtained. Differentially expressed genes (DEGs) of GEO data sets were identified by integrated analysis. The DEGs associated with prognosis were screened in the TCGA data set by univariate survival analysis to obtain a gene signature. A risk score was calculated as the summation of weighted expression levels with coefficients by Cox analysis. The signature was used to distinguish carcinoma, estimated by receiver operator characteristic curves and the area under the curve (AUC).

SUBMITTER: Qiu Z 

PROVIDER: S-EPMC5695251 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature