Cell adhesion regulates gene expression at translational checkpoints in human myeloid leukocytes.

ABSTRACT: Engagement of adhesion molecules on monocytes and other myeloid leukocytes, which are effector cells of the innate immune system, not only tethers the leukocytes in place but also transmits outside-in signals that induce functional changes and alter gene expression. We found that a subset of mRNAs that are induced or amplified by adhesion of human monocytes to P-selectin via its surface ligand, P-selectin glycoprotein 1, have characteristics that suggest specialized translational control. One of these codes for urokinase plasminogen activator receptor (UPAR), a critical surface protease receptor and regulator of cell adhesion and migration. Although UPAR transcripts are induced by adhesion, rapid synthesis of the protein uses constitutive mRNA without a requirement for new transcription an

SUBMITTER: Mahoney TS 

PROVIDER: S-EPMC56953 | biostudies-literature | 2001 Aug

REPOSITORIES: biostudies-literature