Electrosclerotherapy for capillary malformations: study protocol for a randomised within-patient controlled pilot trial.

ABSTRACT:

Introduction

The current state-of-the-art treatment modality for hypertrophic capillary malformations (CMs), laser therapy, has a considerable rate of non-responders and recurrence. Intralesional bleomycin injections (or 'sclerotherapy') are commonly used to treat venous and lymphatic malformations with an excellent effect, but these intravascular injections are not possible in CMs due to the small diameter of the vessels. Electroporation-an electric field applied to the tissue-could increase the permeability of endothelial cells, which could theoretically facilitate targeted localised bleomycin delivery. We therefore hypothesise that bleomycin injections in combination with electroporation-'electrosclerotherapy' (EST), also known as 'electrochemotherapy'-could potentially be a nov

SUBMITTER: Horbach SER 

PROVIDER: S-EPMC5695370 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature