Are IL18RAP gene polymorphisms associated with body mass regulation? A cross-sectional study.

ABSTRACT:

Objectives

To investigate the association between IL18RAP and body mass index (BMI) and obesity and to verify the effect of a polymorphism in the microRNA136 (MIR136) IL18RAP binding region.

Design

We analysed samples from two Spanish cross-sectional studies, VALCAR (Spanish Mediterranean coast) and Hortega (Spanish centre). These studies aimed at analysing cardiovascular risk and development of cardiovascular disease in the general population. Both populations correspond to regions with different characteristics.

Setting

Five IL18RAP single nucleotide polymorphisms were selected using the SYSNPs web tool and analysed by oligonucleotide ligation assay (SNPlex). For the MIR136 functional study, cells were transfected with plasmids containing differ

SUBMITTER: Martinez-Barquero V 

PROVIDER: S-EPMC5695454 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature