Associations of time of day with cardiovascular disease risk factors measured in older men: results from the British Regional Heart Study.

ABSTRACT:

Objective

We estimated associations of time of day with cardiovascular disease (CVD) risk factors measured in older men.

Methods

CVD risk factors (markers of inflammation and haemostasis, and cardiac markers) were measured on one occasion between 08:00 and 19:00 hours in 4252 men aged 60-79 years from the British Regional Heart Study. Linear models were used to estimate associations between time of day and risk factors. When an association was found, we examined whether the relationship between risk factors and cardiovascular mortality was affected by the adjustment for time of day using survival analyses.

Results

N-terminal pro-brain natriuretic peptide (NT-proBNP) levels increased by 3.3% per hour (95% CI 1.9% to 4.8%), interleukin-6 (IL-6) increased by 2.6% per hou

SUBMITTER: Sartini C 

PROVIDER: S-EPMC5695475 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature