Candidate genes-based investigation of susceptibility to Human African Trypanosomiasis in Cote d'Ivoire.

ABSTRACT: Human African Trypanosomiasis (HAT) or sleeping sickness is a Neglected Tropical Disease. Long regarded as an invariably fatal disease, there is increasing evidence that infection by T. b. gambiense can result in a wide range of clinical outcomes, including latent infections, which are long lasting infections with no parasites detectable by microscopy. The determinants of this clinical diversity are not well understood but could be due in part to parasite or host genetic diversity in multiple genes, or their interactions. A candidate gene association study was conducted in Côte d'Ivoire using a case-control design which included a total of 233 subjects (100 active HAT cases, 100 controls and 33 latent infections). All three possible pairwise comparisons between the three phenotypes were te

SUBMITTER: Ahouty B 

PROVIDER: S-EPMC5695625 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature