Identification and management of Shigella infection in children with diarrhoea: a systematic review and meta-analysis.

ABSTRACT:

Background

Shigella infections are a leading cause of diarrhoeal death among children in low-income and middle-income countries. WHO guidelines reserve antibiotics for treating children with dysentery. Reliance on dysentery for identification and management of Shigella infection might miss an opportunity to reduce Shigella-associated morbidity and mortality. We aimed to systematically review and evaluate Shigella-associated and dysentery-associated mortality, the diagnostic value of dysentery for the identification of Shigella infection, and the efficacy of antibiotics for children with Shigella or dysentery, or both.

Methods

We did three systematic reviews (for mortality, diagnostic value, and antibiotic treatment of Shigella and dysentery), and meta-analyses where appropri

SUBMITTER: Tickell KD 

PROVIDER: S-EPMC5695759 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature