Supraglottic squamous cell carcinomas have distinctive clinical features and prognosis based on subregion.

ABSTRACT:

Objective

To analyze the clinicopathologic characteristics and prognosis of patients with squamous cell carcinoma localized to different supraglottic subregions.

Methods

Clinicopathologic data were reviewed retrospectively for 111 patients with supraglottic squamous cell carcinoma who were diagnosed between January 1, 1995 and December 31, 2005 and were initially treated with surgery. DNA from human papillomavirus (HPV) 16 and (or /and) HPV 18 were detected in all the 111 supraglottic carcinoma specimens using in situ hybridization. Survival analysis was performed by Kaplan-Meier analysis, factors were compared using log-rank test, and prognostic factors were determined using Cox proportional hazards model. The relationship between subregions and clinicopathologic factors wa

SUBMITTER: Ding W 

PROVIDER: S-EPMC5695779 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature