Measuring the microbiome of chronic wounds with use of a topical antimicrobial dressing - A feasibility study.

ABSTRACT:

Background

Polymicrobial communities colonize all wounds, and biofilms are hypothesized to be a key link to the chronic state and stalled healing. Molecular methods offer greater insight when studying microbial ecology in chronic wounds, as only a small fraction of wound bacteria are cultured by currently available methods and studies have shown little agreement between culture and molecular based approaches. Some interventions, like dressings with oxidized silver, are reported to help the stalled wounds move to a normal healing trajectory but the underlying mechanisms are difficult to measure. One hypothesis is that the use of topical antimicrobial dressings targets the wound microbiome and reduces bioburden.

Objectives

Our objective was to determine if culture-independent

SUBMITTER: Kalan L 

PROVIDER: S-EPMC5695787 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature