Advances in applied homeostatic modelling of the relationship between thyrotropin and free thyroxine.

ABSTRACT: INTRODUCTION:The relationship between pituitary TSH and thyroid hormones is central to our understanding of thyroid physiology and thyroid function testing. Here, we generated distribution patterns by using validated tools of thyroid modelling. METHODS:We simulated patterns of individual set points under various conditions, based on a homeostatic model of thyroid feedback control. These were compared with observed data points derived from clinical trials. RESULTS:A random mix of individual set points was reconstructed by simulative modelling with defined structural parameters. The pattern displayed by the cluster of hypothetical points resembled that observed in a natural control group. Moderate variation of the TSH-FT4 gradient over the functional range introduced further flexibility, imp

SUBMITTER: Hoermann R 

PROVIDER: S-EPMC5695809 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature