Pre-pubertal exposure with phthalates and bisphenol A and pubertal development.

ABSTRACT:

Objective

Epidemiological studies indicate associations between childhood exposure with phthalates and bisphenol A (BPA) and the pubertal development. We examined associations between the pre-pubertal phthalate and BPA body burden and the longitudinally assessed sexual maturation of eight- to thirteen-year-old children.

Methods

We started with eight- to ten-year-old children in the baseline study and quantified phthalate metabolites and BPA in 472 urine samples (250 boys; 222 girls; mean age: 8.8 years). Associations between the pubertal development, assessed in three annual follow-up studies by Puberty Development scale questionnaires (PD scales), and the chemical exposure from the baseline visit were longitudinally analyzed with generalized estimation equations.

Results

SUBMITTER: Kasper-Sonnenberg M 

PROVIDER: S-EPMC5695814 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature