The importance of mean time in therapeutic range for complication rates in warfarin therapy of patients with atrial fibrillation: A systematic review and meta-regression analysis.

ABSTRACT:

Background

\Anticoagulation is used for stroke prophylaxis in non-valvular atrial fibrillation, amongst other by use of the vitamin K antagonist, warfarin. Quality in warfarin therapy is often summarized by the time patients spend within the therapeutic range (percent time in therapeutic range, TTR). The correlation between TTR and the occurrence of complications during warfarin therapy has been established, but the influence of patient characteristics in that respect remains undetermined. The objective of the present papers was to examine the association between mean TTR and complication rates with adjustment for differences in relevant patient cohort characteristics.

Methods

A systematic literature search was conducted in MEDLINE and Embase (2005-2015) to identify eligible

SUBMITTER: Vestergaard AS 

PROVIDER: S-EPMC5695846 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature