Quantitative label-free proteomic analysis of human urine to identify novel candidate protein biomarkers for schistosomiasis.

ABSTRACT:

Background

Schistosomiasis is a chronic neglected tropical disease that is characterized by continued inflammatory challenges to the exposed population and it has been established as a possible risk factor in the aetiology of bladder cancer. Improved diagnosis of schistosomiasis and its associated pathology is possible through mass spectrometry to identify biomarkers among the infected population, which will influence early detection of the disease and its subtle morbidity.

Methodology

A high-throughput proteomic approach was used to analyse human urine samples for 49 volunteers from Eggua, a schistosomiasis endemic community in South-West, Nigeria. The individuals were previously screened for Schistosoma haematobium and structural bladder pathologies via microscopy and ultr

SUBMITTER: Onile OS 

PROVIDER: S-EPMC5695849 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature