Ab initio chemical safety assessment: A workflow based on exposure considerations and non-animal methods.

ABSTRACT: We describe and illustrate a workflow for chemical safety assessment that completely avoids animal testing. The workflow, which was developed within the SEURAT-1 initiative, is designed to be applicable to cosmetic ingredients as well as to other types of chemicals, e.g. active ingredients in plant protection products, biocides or pharmaceuticals. The aim of this work was to develop a workflow to assess chemical safety without relying on any animal testing, but instead constructing a hypothesis based on existing data, in silico modelling, biokinetic considerations and then by targeted non-animal testing. For illustrative purposes, we consider a hypothetical new ingredient x as a new component in a body lotion formulation. The workflow is divided into tiers in which points of departure are

SUBMITTER: Berggren E 

PROVIDER: S-EPMC5695905 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature