Drosophila Embryonic Hemocytes Produce Laminins to Strengthen Migratory Response.

ABSTRACT: The most prominent developmental function attributed to the extracellular matrix (ECM) is cell migration. While cells in culture can produce ECM to migrate, the role of ECM in regulating developmental cell migration is classically viewed as an exogenous matrix presented to the moving cells. In contrast to this view, we show here that Drosophila embryonic hemocytes deposit their own laminins in streak-like structures to migrate efficiently throughout the embryo. With the help of transplantation experiments, live microscopy, and image quantification, we demonstrate that autocrine-produced laminin regulates hemocyte migration by controlling lamellipodia dynamics, stability, and persistence. Proper laminin deposition is regulated by the RabGTPase Rab8, which is highly expressed and required in

SUBMITTER: Sanchez-Sanchez BJ 

PROVIDER: S-EPMC5695906 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature