Genetic variants and risk of asthma in an American Indian population.

ABSTRACT:

Background

Asthma is recognized as a complex, multifactorial disease with a genetic component that is well recognized. Certain genetic variants are associated with asthma in a number of populations.

Objective

To determine whether the same variants increase the risk of asthma among American Indian children.

Methods

The electronic medical records of an Indian Health Service facility identified all children between 6 and 17 years of age with case-defining criteria for asthma (n = 108). Control children (n = 216), matched for age, were also identified. Real-time polymerase chain reaction assays were used to genotype 10 single-nucleotide polymorphisms (SNPs) at 6 genetic loci. Genotypic distributions among cases and controls were evaluated by χ² and logistic reg

SUBMITTER: Best LG 

PROVIDER: S-EPMC5695928 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature