Age, vascular health, and Alzheimer disease biomarkers in an elderly sample.

ABSTRACT:

Objective

To investigate the associations between age, vascular health, and Alzheimer disease (AD) imaging biomarkers in an elderly sample.

Methods

We identified 430 individuals along the cognitive continuum aged >60 years with amyloid positron emission tomography (PET), tau PET, and magnetic resonance imaging (MRI) scans from the population-based Mayo Clinic Study of Aging. A subset of 329 individuals had fluorodeoxyglucose (FDG) PET. We ascertained presently existing cardiovascular and metabolic conditions (CMC) from health care records and used the summation of presence/absence of hypertension, hyperlipidemia, cardiac arrhythmias, coronary artery disease, congestive heart failure, diabetes mellitus, and stroke as a surrogate for vascular health. We used global amyloid fro

SUBMITTER: Vemuri P 

PROVIDER: S-EPMC5696029 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature