Chromatin organization as an indicator of glucocorticoid induced natural killer cell dysfunction.

ABSTRACT: It is well-established that psychological distress reduces natural killer cell immune function and that this reduction can be due to the stress-induced release of glucocorticoids. Glucocorticoids are known to alter epigenetic marks associated with immune effector loci, and are also known to influence chromatin organization. The purpose of this investigation was to assess the effect of glucocorticoids on natural killer cell chromatin organization and to determine the relationship of chromatin organization to natural killer cell effector function, e.g. interferon gamma production. Interferon gamma production is the prototypic cytokine produced by natural killer cells and is known to modulate both innate and adaptive immunity. Glucocorticoid treatment of human peripheral blood mononuclear cel

SUBMITTER: Misale MS 

PROVIDER: S-EPMC5696065 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature