Acid-sensing T cell death associated gene-8 receptor expression in panic disorder.

ABSTRACT:

Background

While disruption of acid-base homeostasis has been pathoetiologically implicated in panic disorder (PD), the mechanism by which pH imbalance is translated to panic pathophysiology is poorly understood. Recently, in a translational rodent model of PD, we reported a role of microglial acid sensing G-protein coupled receptor, T cell death associated gene-8 (TDAG8) in panic-associated behavior and physiology. However, the clinical validity of the TDAG8 receptor has not been investigated.

Objective

To assess TDAG8 in PD, we evaluated TDAG8 receptor expression in adolescents and young adults with PD and healthy comparison subjects.

Methods

Relative expression of TDAG8 mRNA was determined in peripheral blood mononuclear cells from patients with PD, and compared to

SUBMITTER: Strawn JR 

PROVIDER: S-EPMC5696091 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature