MiR-205 as a promising biomarker in the diagnosis and prognosis of lung cancer.

ABSTRACT: MicroRNA-205 (miR-205) was revealed as a novel diagnostic and prognostic biomarker for lung cancer, but the results in the published papers were inconsistent. This meta-analysis aimed to investigate the diagnostic and prognostic roles of miR-205 in patients with lung cancer. Totally, 16 eligible articles were included, among which 10 articles investigated the diagnostic value of miR-205, 5 articles examined its prognostic values, and 1 article studied both diagnostic and prognostic values. For the diagnostic meta-analysis, the pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and the overall area under the curve of miR-205 for patients with lung cancer were 0.88 (95% CI = 0.78 - 0.94), 0.78 (95% CI = 0.66 - 0.86), 4.

SUBMITTER: Li JH 

PROVIDER: S-EPMC5696153 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature