Downregulation of tumor suppressive microRNAs in vivo in dense breast tissue of postmenopausal women.

ABSTRACT: Women with dense breast tissue on mammography are at higher risk of developing breast cancer but the underlying mechanisms are not well understood. De-regulation of microRNAs (miRNAs) has been associated with the onset of breast cancer. miRNAs in the extracellular space participate in the regulation of the local tissue microenvironment. Here, we recruited 39 healthy postmenopausal women attending their mammography-screen that were assessed having extreme dense or entirely fatty breasts (nondense). Microdialysis was performed in breast tissue and a reference catheter was inserted in abdominal subcutaneous fat for local sampling of extracellular compounds. Three miRNAs, associated with tumor suppression, miR-193b, miR-365a, and miR-452 were significantly down-regulated in dense breast tissue

SUBMITTER: Abrahamsson A 

PROVIDER: S-EPMC5696169 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature