Profile of differentially expressed Toll-like receptor signaling genes in the natural killer cells of patients with Sezary syndrome.

ABSTRACT: Sézary syndrome (SS), an aggressive and leukemic form of cutaneous T-cell lymphoma, usually results in shortened survival. Improving innate immunity in SS by targeting natural killer (NK) cells with Toll-like receptor (TLR) agonists could be an interesting modulatory strategy. We evaluated the NK cell populations in SS patients assessing activating and inhibitory receptors expression and profiled the differential expression of TLR signaling pathway genes in unstimulated NK cells and after TLR7/8 stimulation. We observed preserved CD56^bright NK cells and a low percentage of CD56^dim NK cells in the peripheral blood of SS patients compared to those in the healthy control group. Both NK cell populations showed down-modulation of NKG2C and NKG2D expression, which was assoc

SUBMITTER: ManfrereC KCG 

PROVIDER: S-EPMC5696173 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature