Genomic copy number gains of ErbB family members predict poor clinical outcomes in glioma patients.

ABSTRACT: The aim of this study was to investigate copy number of ErbB family members (including EGFR, HER2, HER3 and HER4) in a cohort of gliomas and benign meningiomas (control subjects), and explore the associations of their copy number with clinicopathological characteristics and clinical outcomes of glioma patients. Using real-time quantitative PCR assay, we demonstrated that copy number of EGFR, HER2, HER3 and HER4 in glioma patients was significantly increased compared to control subjects. Moreover, our data also showed that the risk of cancer-related death was positively associated with copy number gain (CNG) of EGFR, HER3 and HER4, but not HER2. CNG of EGFR and HER2 was positively related to radiother

SUBMITTER: Liu R 

PROVIDER: S-EPMC5696180 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature