Plasma lipid profiling and diagnostic biomarkers for oral squamous cell carcinoma.

ABSTRACT: Biological requirements for tumor cell proliferation include the sustained increase of structural, energetic, signal transduction and biosynthetic precursors. Because lipids participate in membrane construction, energy storage, and cell signaling. We hypothesized that the differences in lipids between malignant carcinoma and normal controls could be reflected in the bio-fluids. A total of 100 pre-operative plasma samples were collected from 50 oral squamous cell carcinoma (OSCC), 50 normal patients and characterize by lipid profiling using ultra performance liquid chromatography/electro spray ionization mass spectrometry (UPLC-MS). The lipid profiles of the OSCC and control samples as well as the different stages were compared. Differentially expressed lipids were categorized as glyceropho

SUBMITTER: Wang L 

PROVIDER: S-EPMC5696184 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature