Prediction model of hepatocellular carcinoma risk in Asian patients with chronic hepatitis B treated with entecavir.

ABSTRACT:

Background

Until now, no risk score could predict hepatocellular carcinoma (HCC) in nucleos(t)ide analog (NA)-treated Asian patients.

Methods

We enrolled 1325 NA-naïve chronic hepatitis B patients with entecavir monotherapy for >12 months, with 883 and 442 patients randomly assigned to the development and validation groups, respectively, in the risk model.

Results

The cumulative probabilities of HCC were 2.4%, 4.1%, and 9.9% after 2, 3, and 5 years of treatment, respectively. In the development group, age, platelet counts, and alpha-fetoprotein levels after 12 months of treatment were the independent predictors of HCC. We converted the Cox proportional hazards regression coefficients for these predictors into risk scores and developed the APA-B model, with the total r

SUBMITTER: Chen CH 

PROVIDER: S-EPMC5696194 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature