Distribution pattern of tumor associated macrophages predicts the prognosis of gastric cancer.

ABSTRACT:

Purpose

As mayor biomarkers in tumor microenvironment (TME), tumor associated macrophages (TAMs) of gastric cancer (GC) still needs further studies in terms of the number and distribution pattern.

Methods

Herein, tissue microarrays (TMA) incorporating 494 GC surgical samples in duplicate were stained for TAMs infiltration analysis. TAMs number was counted according to the locations, including infiltrating macrophages in cancer nest (MC), in invasive front (MF) and in stroma (MS). Correlations between TAMs number, distribution pattern and clinic-pathological features and survival analyses were performed.

Results

Infiltrating macrophages number in GC tissues was much higher than that in peritumoral tissues. TAMs number was not significantly correlated with the overall s

SUBMITTER: Liu JY 

PROVIDER: S-EPMC5696219 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature